Human Cloning (Geek-Alert)

Nov 27, 2007 03:52

So I was sitting at a night-club with some friends this evening discussing literature while the Burlesque performers were practicing getting their pasties gyrating in unison back stage.

Both my friend and I had read all of Heinlein's Lazarus Long stories, however his girl-friend had never heard of them. We covered some of the back-plot including ( Read more... )

ultrageek cloning lazarus heinlein

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Re: Not a biochemist.... azraphael November 27 2007, 12:04:13 UTC
From what I understand, the base-pair sequence of the DNA doesn't change. Instead there are two changes that occur to the DNA:

Chemical DNA Change: A process called DNA Methylation chemically modifies the Cytosine (the C in the G-C / A-T base-pairs). Methylation of a genes Cytosine can prevent the gene from functioning by blocking it's transcription. This chemical change is persistent across cell division - see Epigenetic Inheritance.

DNA Methylation is reversed in a process surprisingly called Demethylation. This process occurs in the development of spermatozoa prior to fertilization and the formation of the zygote.

Structural DNA Change: Histone buildup around a genes DNA results in the DNA becoming tightly bound. This tight binding limits the genes functioning by restricting its transcription. This binding is persistent across cell division - see Epigenetic Inheritance.

Histone binding appears to be present in the spermatozoa and in the zygote, however the spermatozoa histone appears to be 'cleaned' before the first round of cell-replication.

Turkey Baster: I'm certain there are more pleasurable applicators than the turkey baster!

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